ABSTRACT
Background Critically ill COVID-19 patients are at risk of developing major complications with high mortality rate. Aspirin might have favorable effects in severe COVID-19 via various mechanisms besides inhibition of platelet aggregation. The role of aspirin as adjuvant therapy in critically ill patients with COVID-19 has not been studied. In this study, we investigated the correlation between aspirin use and the clinical outcome in critically ill COVID-19 patients. Methods This is a retrospective cohort observational study of critically ill COVID-19 Egyptian patients. Participants were divided into two groups: patients who received aspirin, 150 mg per day orally, upon admission to the intensive care unit, and those who did not. The primary outcome in this study was the shift to invasive ventilatory support. Results A total of 1190 patients were involved in the study, 660 patients received aspirin, while 530 patients did not. Among aspirin group compared to non-aspirin group, invasive ventilatory support, DVT, PE, stroke, ACS, ARDS, AKI, septic shock, and mortality were less frequent, and the differences were significant except for ACS, AKI, and septic shock. Major bleeding was non-significantly more frequent. The length of ICU stay was significantly longer among non-survivors, and shorter among survivors. The variations between the two groups were significant among subgroups >= 40 or 60. Conclusions In critically ill patients with COVID-19, aspirin has the potential role as an adjuvant therapeutic, lowering the risk of mechanical ventilation, thromboembolic events, ARDS, and ICU mortality. Patients older than 40 years were a significant category that might benefit from aspirin.
ABSTRACT
Background: Pregnancy is a condition of partial immune suppression which makes pregnant women riskier to viral infections, and the morbidity is increased even with seasonal influenza. Therefore, the COVID-19 epidemic may have dangers consequences for pregnant women. Although the high incidence of cases of COVID-19 are currently in China, the risk of outward transmission appears to be significantly high global concern. Objectives: To assess pregnant women's practices about prevention of covid 19 before and after implementation of instruction program and to determine the effectiveness of instruction program on pregnant women practices about prevention methods of corona virus, covid 19 in PHCC in Kirkuk city. Methods: A quasi-experimental design was conducted during the period from (6th may 2021 through 20th August 2021) on non-probability sample (purposive) consists of (100) pregnant women) who visited the primary health care center. The sample practices was exposed to pretest, educational program, posttest. The study was conducted in Kirkuk city, Kirkuk health Director, three primary health care centers from the Kirkuk 1st sector which include (Al- Mansur center for primary health care, Al-Wassity center for primary health care, and Bader center for primary health care), than select three primary health care centers from Kirkuk 2nd sector which include (AL-Rasheed center for Primary health care, Azady center for Primary health care, ALNassir center for Primary health care, and Al- Mansur center for primary health care) Questionnaire was used as a tool of data collection. A pilot study was conducted at Al- Wassity center for primary health care in order to determine the reliability of the study and the testing the pregnant women practices about prevention methods of corona virus diseases 19. Data were collected through the questionnaire. Data were analyzed through the application of descriptive and inferential statistical data analysis approach through the use of (SPSS) version 22.0 and Excel system Results: The results of the study have revealed that significant correlation between pretest and posttest periods after the implementation of education program for pregnant women Practices regarding prevention methods of corona virus and reducing infected by it. There were high significant correlations between pre and post periods at (p. value: 0.101) in evaluation of the effectiveness of the instruction program in the practices of pregnant women on prevention methods to reduce the incidence of infection between Pre and post evaluation. Conclusions: The study concluded that the educational program can be considered as an effective mean for the improvement of the pregnant women's practices about the importance prevention methods of corona virus. Recommendations: Pregnant women should be given instructional booklets in order to raise practice level of preventive measures of COVID-19 infection at the beginning of their pregnancy and who can protect their families' members from such pandemic.
ABSTRACT
The virus that causes (COV- 19 disease), "SARS-CoV-2 disease" is to blame for the greatest epidemic since the (1918) H1N1 influenza pandemic. The World Health Organization presently recognizes coughing, the fever, exhaustion, and breathing problems as symptoms. Despite the fact that patientreported a loss of flavor and smell has been linked to, there is not olfactory data collected empirically, testing on a group of "COV-19" infected persons with COVID-19 infection. The virus of corona, which spreads by using the same receptor as 'SARS-CoV' primarily by using the mechanism of respiration, angiotensin-converting enzyme 2. Importantly, there had been growing the proof of prolonged transmission from one person to another, as well as a large number of cases exported over the world. This article provides a critical assessment SARS CoV-2 infection and therapy options for COV - 19.
ABSTRACT
Background Surgical-site infections (SSIs) are found to occur after about 2-5% of all surgeries. SSIs have many drawbacks such as the need for readmission, revision operations, prolonged duration of hospital stay, increased financial burden on patients and increased risk of worsening outcome in cancer patients. Closed-incision negative-pressure therapy (CINPT) was studied as a method of preventing infections in wounds occurring after closed surgical incisions particularly during the covid-19 pandemic. There are many studies showed promising results of this procedure. Therefore, in this prospective clinical randomized study, we aimed to evaluate the benefit of performing prophylactic CINPT in controlling SS's in open colorectal surgeries, hepatobiliary surgeries and gynecological cancer surgeries involving laparotomies, in comparison with the standard dressings. Patients and method We included 120 patients of SS's with open colorectal surgeries, hepatobiliary surgeries and gynecological cancer surgeries involving laparotomies in the period between 2015 and 2020. We divided the patients randomly into two groups: the first group is the study group, which included 30 patients managed by CINPT, and the second group is the control group, which included 90 patients managed by standard non-CINPT management. We compared patients who underwent CINPT with the control group of high-risk patients undergoing routine management non- CINPT procedures. Results The median rate of occurrence of general adverse wound outcomes was 32.5% for all the included patients: 20% in the CINPT group and 36.7% in the control group (P =0.049). The median rate of occurrence of SS's was 17.5% for all the included patients: 7% in the CINPT group and 15% in the control group (P=0.001). Time to diagnose SS's in the CINPT group was longer than that in the control group (19 vs 13 days;P=0.03). The increased duration of operation and the presence of preoperative or postoperative stoma were associated with increased incidence of occurrence of SSI, while CINPT was associated with decreased incidence of occurrence of SS's (P<0.001). Conclusion We observed a marked reduction in the rates of SS's in closed laparotomy wounds in colorectal, hepato-pancreato-biliary and in gynecological oncology surgeries managed with prophylactic CINPT particularly during the Covid-19 pandemic.
ABSTRACT
COVID-19 spreads abnormally compared to its counterparts in the same family "beta-coronaviruses". Today, we count more than 130 million affected humans affected by the COVID-19. Therefore, the study of means of prevention and treatment is an urgent need. Interestingly, the novel virus (SARS-CoV-2) has some similarities with SARS-CoV and MERS-CoV. It is known that heterologous immunity is well recognized within species of the same family. The use of previously recognized effective antibodies for SARS and MERS virus may prevent the COVID-19 pandemic. The objective of this study is to compare between SARS-CoV, MERS-CoV, and SARS-CoV-2 genomic and proteomic identity/similarity and their cross-immunity as well as their immunological features in the context of COVID-19 diseases prevention and treatment methods.
ABSTRACT
Background: Chest CT is an essential and simple diagnostic method for early detection of pulmonary changes in COVID-19 patients. Semi-quantitative technique depending on both visual and color coded images helps to improve the early detection of COVID-19 chest affection and thus help to control spread of infection. Results: From first of May to July 15, 2020, 30 patients in Cairo, Egypt who have positive RT-PCR tests and positive pulmonary manifestation were included in our study, 26 patients (86.6%) with faint ground glass opacities were detected by both visual and color coded images, while in 4 patients (13.3%) were only visualized by color coded images and confirmed by CT density assessment. Conclusion: The combined use of visual and color coded images enhance and improve the early detection of faint ground glass opacities seen in early COVID-19 affection. © 2020, The Author(s).